Long Beach, CA City Guide

7 Little Known Acne Skin Care Secrets

An acne problem is not a problem, so long as you know wise acne skin care tips. One does need much money to get that healthy glowing skin, with the natural acne skin care methods, acne shouldn’t be treated like monsters under your bed. Here are some acne skin care methods we can practice.

<b>The power of water.</b> Oil, they say is thicker than water. But water is the plainest, most natural substance we can use for acne skin care. In washing your face, do it gently. Rubbing and scrubbing your face does not clean the skin gently. For best acne skin care effects, using a mild cleanser or toner once in the morning, noon and evening, and after doing a heavy work out, will help you achieve a clear skin.

Pick that zit. People who prick pimples and blemishes as if pricking a bubble only aggravates the risk of skin inflammation and acne scars. Avoid hand contact with your face for better acne skin care results.

Shave with care. Choose the best electric shavers and safety razors you can trust for years. They’ll be more comfortable to use. Men need not use a super sharp blade to get rid of that beard. A regular shaver used with soap and water, or shaving cream will help you get that smooth finish. Doctors advised men to shave lightly, and shave only when necessary for acne skin care maintenance .

Sun of the beach!If you love sun tanning or just want the sight of that sophisticated sunburnt look – forget it. This is an acne skin care no-no. The sun’s harmful ultra violet rays redden the skin, making the skin drier. It can make one’s blemishes visible, speed up aging and bring serious damage to the human skin. Also, excessive exposure to the sun can cause skin cancer. You don’t want to ruin that great acne skin care you’ve been starting on with.

Cosmic Cosmetics. Eye shadows, blush on, moisturizer, and other cosmetics we use should be free from oily substances to permit healthy acne skin care maintenance. Even hairstyling products in forms of gels or aerosols that come in close contact with the skin may destroy a healthy acne skin care practice. Choose hairstyling products, which are commercially labeled as non-comedogenic are products which do not provoke the formation and growth of blemishes and other related skin
disorders.

Buttered Face.An African beauty secret reveals the power of shea butter which originated from the Karite Nut Tree (or Mangifolia tree). Hmmm… juicy acne skin care tip! Karite Nut Tree was discovered in the semi-arid savannahs of West Africa and Central Africa. People in Africa, women in particular – rely in shea butter as a vital tool for acne skin care treatment for over centuries now.

Spare me that SPA! You need not visit the most expensive spa parlors to get that destressing facial treatment to aid you in your acne skin care endeavor. Create a home made magical elixir right at the comforts of your own home by purchasing simple spa tools found in beauty stores.

Get only the best and the FRESH. Increase intake of fresh fruit and vegetables. These acne skin care tools are free of toxins which decreases the speed of blood circulation. A salad or a fruit a day will keep an acne away!

There is no perfect cure, medication, treatment or acne skin care methods for acne problems. Thus, as the sole proprietor of our own skin, we must take full charge of what lies to be our first armor against diseases and bodily injuries.

If you want to get away from leaving with acne and zits http://www.fightingacne101.info

Acne Skin Care Secrets

An acne problem is not a problem, as long as you tips know wise acne skin care. You need need money to get healthy radiant skin, acne not as Monster under the bed should be treated with the natural acne skin care methods. Here you will see some acne skin care methods we can practice.

The power of water. Oil, they say, is thicker than water. But the water is the easiest, most natural substance we can skin care to use for acne. In washing your face, then do it gently. Not clean your face friction and scouring the skin gently. For the best acne skin care be achieved is with a mild detergent or toner once in the morning, noon and night, and after I one heavy work, help a clear skin.

Pick, that zit. Persons in the sharp Pickeln and spots as if a bubble only exacerbated uses the danger of inflammation of the skin and acne scars. Avoid direct contact with your face for one better acne skin care results.

http://pubchin.com/health-beauty/acne-scar-removal/

Shave with care. Choose the best electrical Razaq and trust Rasierklingen years. You are still more comfortable to use. Men do not need to rid a super sharp blade that beard. A regular Razaq used with SOAP and water or shaving foam will help you, the smooth surface. Doctors who to people lightly shave, shave and only when needed for acne skin care maintenance.

Sun of the beach! If you love that Sun can or want to find just the sight of this demanding sunburn – forget it. This is an acne skin care-no no. The Sun röten harmful ultraviolet rays dry the skin, makes the skin. It can speed make one’s visible, aging spots and bring severe damage to the human skin. Excessive exposure to the Sun caused can also skin cancer. You refuse that large acne skin ruin care you already off with.

Cosmic cosmetics. Eye shadow, Rouge, we use moisturizing cream and other cosmetics should free to allow oily substances, healthy acne skin care maintenance. Also hair styling products in form of gels or sprays that can come in close contact with the skin contact to destroy a healthy acne skin care practice. Choosing products not irritate the formation and growth of spots and other related skin disorders hair styling products that are not labeled as are komedogen in trade.

http://pubchin.com/health-beauty/acne-scar-removal/

Butter face. An African beauty secret revealed the power of Shea butter from the karite nut tree (or Mangifolia tree) is created. Hmmm… lush acne skin care tip! Karite nut tree was discovered in the semi-ariden, West Africa and Central Africa. People in Africa to appoint women in particular-, Shea butter as an essential instrument for acne skin care treatment over the centuries now.

Spare me, that SPA! You must not visit to get that you seek destressing facial in your acne skin care help the most expensive Spa Salon. Create a homemade magic elixir directly to the comfort of own home buying simple technique in spa beauty shops.

Get only the best and FRESH. Increase in consumption of fresh fruit and vegetables. This acne skin care tools are free from perspiration which increases the speed of blood flow. A salad or fruit is day keep an acne!

There are no perfect cure medicines, treatments, acne skin care methods for acne problems. So as the sole owner of own skin we need the full load of, what is our first tanks against diseases and physical injuries.

http://pubchin.com/health-beauty/acne-scar-removal/

More Clear Acne Naturally Tips and other Related Resources:

Acne No More – is a natural acne remedy by Mike Walden. His guide for permanently curing acne is said to give miraculous results in less than 7 days. Mike Walden claims that Acne No More documents a natural and holistic, clinically proven method that he developed over the course of 7 years. A method that he says has thousands of satisfied customers to date.

Acne Free in 3 Days – is a leading acne removal remedy authored by Chris Gibson that claims to completely remove acne, pimples, and zits in a 3 day process. The primary benefits as stated by the Acne Free in 3 Days website are that the process is safe, inexpensive, and all natural. It is also claimed by Chris Gibson that in most cases, acne can be cured in only 3 days.

Mr. X Acne Cure – is an eBook written by a 25 year old British man who calls himself “Mr. X”. Mr. X claims to have had chronic acne since he was a teenager and tried every prescription acne treatment available to no avail. Only after extensive research on the effects of food on the body did Mr. X claim to have cracked the acne code. It’s a simple process to cure your acne once and for all at a fraction of the cost of any other alternative. It’s quicker, easier, safer, and it has worked for thousands of people.

Spring and Summer Skin Care Regimen

April showers bring May flowers. The old adage is definitely true. We suffer through the rain falls of early Spring to be greeted by the cheery blooms that follow. However, May flowers are not all that comes from April showers, but so does hot, humid weather. And this sudden spike in temperature and humidity is a sign that our skin care regimens need a change.

Cleanse, exfoliate, tone and moisturize – these are the absolute basics of good skin care, and the importance of each step will shift significantly depending upon the season. In winter months moisturizing is key because having adequate moisture in the skin not only helps the skin to repair any damage, but it also helps to prevent damage caused by severe dryness.

In the summer months, however, our primary skin care focus switches from moisturization to exfoliation. This is due to the spike in temperatures causing our body temperatures to rise and our oil glands to become more productive, producing excess amount of pore-clogging sediments. Here is a fail-proof Summer skin care regimen to keep the skin of your face and body glowing well into the fall.

Step 1 – Cleanse. Cleansing is always the first step to beautiful skin. Dirt, pollution, and oil produced by the body cling to the face and not only clog pores but create a dull residue. Cleansing with an alcohol-free face wash is the best was to remove the garbage and prep the skin for steps 2-4. In the winter months cleansing becomes less important, and one can get by with only cleansing every other day, due to the lack of humidity. But in the Summer, cleansing becomes priority, and should be done at least once a day for dry and normal skin and twice a day for oily skin.

Step 2 – Exfoliate. Exfoliation is the way in which dead skin cells, which cause dullness, blotchiness, and variations in skin tone, are gently removed from the epidermis and allow the fresh new skin underneath to be exposed. Be careful when exposing this newly exposed skin to the damaging rays of the sun. By removing the protective, but unattractive layer of dead skin we are removing a natural protective shield. Be sure to use sunblock at all times, whether you plan to be exposed directly to the sun or not. The sun’s rays have a mysterious way of penetrating almost everything we think to be a “barrier”.

Exfoliation does not have to be a daily step in your skin care routine, as individuals skin cells die at different rates. People with normal skin tones can get by with exfoliating two times per week in the spring and summer. Also, if you have sensitive skin or are prone to acne breakouts, exfoliate at your own risk!! Consider using an exfoliant made specifically for acne or sensitive skin. Maky times the exfoliant property will be smaller more granulated than those for normal to oily skin, which tend to be larger pieces of sand or ground walnut. The best type of exfoliant for all skin types is one that contains micro beads.

Step 3 – Tone. Always, always, always tone your face after cleansing or exfoliating. Whichever step is last in your routine, tone when finished. A great non-alcoholic toner will not only balance the ph (acid) levels in the skin, which can be askew after cleaning and exfoliating, but it will also close the pores, which were opened by cleansing, and they will be less suseptible to foreign pathogens being allowed to enter. Toner can also be carried around in the summer to the beach, the pool, or an outdoor picnic, and applied as desired to ass moisture to the face. It also has a cooling effect, which is always a nice break from the heat.

Step 4 – Moisturize. As mentioned earlier, moisturization in much more important in winter months than summer, however this is a step that absolutely cannot be skipped. Be sure that your summer moisturizer contains a sunscreen with a high SPF, and one that is free of paba, jojoba oil, and lanolin oil. These products will only clog pores causing breakouts and infections.

In the heat of the summer the best thing we can do for our complexion is to keep it as clean as possible. Breakout levels are higher in spring and summer months because our sebaceous glands are much more active then in the fall and winter. Was your face often, and be sure to tone and use a moisturizer that contains sunscreen. Apply is lightly to the skin.

Apply these tips, and miner changes to your daily skin care regimen and you will have a flawless, glowing complexion all summer long.

Skin Care Help is dedicated to providing skincare tips and techniques for those with normal and problem skin. Also providing expert opinion and skin care product reviews.

Hair Care Tips for Hot and Humid Climate

Hair care must be changed as the season and climate changes. Remember that to stay away from the dandruff and baldness, you need to take the good care of your hairs. Special hair care techniques should be used during the hot and humid climate otherwise you may end up with the lot of dandruff in the hairs. Your hairs will become rough due to the more concentration of the salt in the sea coastal areas. In the hot and humid climate your hairs make change the color and get dry due to the high temperature even the color of your hairs may be changed. Hair loss is promoted in such an environmental condition. So, here are some hair care tips that should be followed during the hot and humid climate:

1. Wash your hairs regularly. This will help to remove the particles of dust that are carried along with the humid air. In washing process allow your hairs to rinse at least for 10 minutes in the soap (use special liquid soaps or conditioners for hairs) before you clean them with water. This helps to clean hairs thoroughly.

2. When in the sun make it a point to cover the hairs with the cap otherwise it may be harmful to your hairs. They may get dry, which would make them thin, thus they will broke or fall easily. You can also tie a bandana for the protection against harmful sunrays.

3. If you go out on a beach then remember to take special hair care because the salt in the water or in the wind may damage your hairs. The best thing would be to apply oil on the hair before you go at the sea shore. The oil will act as the protection layer and will not allow the sand and salt to damage your hairs. While in the sea you can even wear the cap to protect the hairs.

4. Humidity can affect your hair in a bad way in the summer making your hair wilt. Apply some conditioner (suitable for your hairs) to towel dried hair. This will add volume and also detangle your hair. This way you can protect the hair.

5. Remember to apply some little bit of oil once in two days to protect them from getting dry in the hot climate. Oil will make your hair reflective and thus the sun rays will get reflected thus causing less harm to the hair.

6. If you have a long hairs then please tie them up when you are outside. More care needs to be taken of the long hairs. Wash them regularly, keep them clean, and oil them properly to maintain your long hairs at stable condition.

7. Don’t use the drier to dry the hairs during the hot and humid climate because this will put a stress on the already weak hairs and thus will promote the hair loss. Always use a soft towel to dry the hairs.

8. After swimming in the salt water, make it point to wash the hair with tap water. This will remove the salt and chlorine from the hairs.

These are the simple hair care tips that can safeguard your hair from the hot and humid climate. If you use these tips then hair loss can be prevented and you can maintain the hair in better condition.

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Sunny Beaches and Hair Care

For all people, it is very enjoyable to spend summer holidays at beaches, but not for hair. Sunrays and salted water make problem for hair. Every one wants to have the best hairstyle and look after their hair.

A large number of persons have observed that the hair do not shine intensely during the period of summer. As, sun makes dry high coat of hair and concerns albuminous stability. Salted water also has dreadful contact on hair, particularly in the summer holidays while one stays under sun radiations and swims on a regular basis. These two components make hair dull and rough, particularly ends of hair. Hair mostly discontinue shining due to rough surface, they movable elasticity and become very simple to split. Therefore, this is not just a condition of beautiful looking hair, this is a severe condition of hair well-being, and one requires taking care of it.

The main thing an individual require to perform to have strong hair is to keep them from direct Ultraviolet rays- put on headgear. At present, there is a wide range of headgear such as caps, hats, bandanas and panamas. But one should keep in mind that hair should be capable to take breaths, so the great option is a straw hat.

The subsequent thing is the shield from salt. Every time after swimming one should rinse hair very cautiously to remove salt from head skin and hair. A numbers of cosmetics brands have specific items for the time of summer that can look out of hair requirements. These hair care items are particularly associated for those persons who use more time on beaches. When it is preferable to employ two in one formula items in vacation, it is suggested to apply separate conditioner and hair shampoo for care of head skin and hair.

As well as, one should look out of the water-salt equilibrium of complete body. Generally, 1.5 litres or 2 litres every day of healthy liquids will assist one with beauty and health. But always remember, that not every liquid is beneficial and healthy, just natural hair products are suggested such as ice green tea or hot green tea with fresh lemon juice and cold water.

The assist of natural hair masks with further protein can improve concerned albuminous balance. The hair masks should be utilized in curing order – use mask of head skin and hair, cover head with cellophane, after that cover it with dry and soft towel, allow the hair mask stay for 20-25 minutes. At last, rinse the hair properly. One should keep away from chemical actions on hair in the period of summer, as they have their own dreadful contact on hair.

For more information on Sunny Beaches and Hair Care and hair care go to http://www.beautyfeast.com/ Jessica Thomson’s website specializing in care for hair conditions with tips, advice and resources for women, men, teens and babies, including information on the hair care.

Emergency Medical Care Needed For A Kitten With Burns On 30 % Of Her Body. She Wants To Live?

I was wondering if anyone knows of whom could help me with a kitten that was put in a pillow case , and lit on fire and thrown in the alley. We took her to a vet we only had a hundred dollars they.gave her a shot of antibiotics .and shaved a couple of spots by her head. . A week went by we noticed that their were more spots on her body that had bad burns theres no skin .so we took her to another vet paid a hundred and twenty dollars they gave her more antibiotics and shaved all the burns and wrapped her up .. its been a nother week now were out of money she needs medical care. She wants to live so much
Can can anyone tell us how to care for her open burn wounds .and what kind of an
antibiotics thats safe to fight infections . she really needs emergency care its 4:40 am october 31 2006 my name is (caring) Marciene Alexander
1090 Obispo Ave #40
Long Beach, CA , 90804
LOS ANGELES AERA
onegeorgeonedot2001@yahoo.com 562-787-9091 leave message thank you .

Health Care Sector in India

Today India offers World Class Medical Facilities, comparable with any of the western countries. India has state of the art Hospitals and the best qualified doctors. With the best infrastructure, the best possible Medical facilities, accompanied with the most competitive prices, you can get the treatment done in India at the lowest charges.

Patients from around the globe are beginning to realize the enormous potential of modern and traditional Indian medicine. Indian hospitals, medical establishments and the government of India have also realized the potential of this niche segment and have begun to tailor their services for foreign visitors. International marketing divisions have been set up by most of the top India Hospitals like Apollo, Max, Fortis, Wockhardt, etc. Some top medical tourism providers like http://www.TaMedical.com, http://www.India4Health.com, http://www.Mediscapes.com and http://www.IndiaHeals.com are helping the hospitals in this task. At a regional level, this nascent healthcare industry came to limelight with the arrival of ‘Naby Noor’ from Pakistan, who came for her Heart Surgery treatment to a hospital in Bangalore. Quite a few Indian state governments have with time, realized the potential of this ‘Healthcare industry’ and have been actively promoting it.

Visitors, especially from the United States of America, United Kingdom and the middle-east find Indian hospitals a very affordable and viable option to coping with insurance and National medical systems in their respective countries. Travellers prefer to combine their medical treatments with a visit to the ‘exotic east’ with their families, visiting places like the Taj Mahal in Agra, the palaces in Rajasthan, the serene beaches in Goa and the mountains of Kashmir and the backwaters of Kerela among others. The total price of an overseas treatment with airfare, hotel accommodation and even a few days of vacation is often far less than just the procedure cost back in the US or UK.

The year 2003 and 2004 saw a trickle of tourists from the healthcare systems of western countries seeking medical treatment in India. By the year 2005 and 2006 this became a deluge, much of it propelled by a blast of free publicity from programmes like 60 Minutes.

Judging by the buzz in the hospital circuit, it won’t be very long before every cosmopolitan private hospital offers yoga, ayurvedic massages, aromatherapy, mudbaths, pranic healing, reiki and meditation classes. With time more and more visitors will flock to this part of the globe for their treatment and relaxation needs.

Post grad in Sociology. Freelance writer with prior experience of working in the Healthcare sector.

Why Doesnt Obama Stop Pretending To Be Listening To Other Ideas On Health Care?

http://spectator.org/archives/2009/03/11…

As part of his drive to overhaul the nation’s health-care system, President Obama has presented himself as a pragmatist who is more interested in creating the best possible plan than in rigidly adhering to a given ideology.
“It’s conceivable that there are other ideas out there that we have not thought of,” he acknowledged at last Thursday’s White House Health Care Summit. “If there is a way of getting this done where we’re driving down costs and people are getting health insurance at an affordable rate and have choice of doctor, have flexibility in terms of their plans, and we could do that entirely through the market, I’d be happy to do it that way. If there was a way of doing it that involved more government regulation and involvement, I’m happy to do it that way as well. I just want to figure out what works.”
President Obama has used events such as community discussion groups and last week’s summit to foster the impression that he is soliciting opinions from all angles of the health care debate, but the reality is a lot different. Obscured by the Administration’s theatrics is the fact that it has kept at bay those who advocate free-market solutions rather than government-run health care.
The guest list to the summit was a telling sign. Despite having representatives from 169 different labor, industry, and policy organizations, the White House did not invite any organizations that advocate a consumer-based free-market approach to health care.
Progressive organizations such as the Center for American Progress, Health Care for America NOW!, and Campaign for America’s Future were represented, but pro-market groups such as the Cato Institute, Consumers for Health Care Choices, the Galen Institute, or the Council for Affordable Health Insurance were not.
“They brought in the health care establishment to basically divvy up the pie, and consumers were left out of it entirely,” lamented Greg Scandlen, president of Consumers for Health Care Choices. “This is all predetermined and orchestrated to get the result they want.”
While the Republican Congressional leadership was on hand, many of the foremost proponents of a patient-focused approach to health care were not.
“I suspect that that can’t be an accident,” Rep. John Shadegg, a Republican who has proposed a number of market-oriented reforms to the U.S. health care system and did not receive an invitation to the summit, said. “I suspect that they don’t want those views expressed.”
Shadegg noted that other lawmakers who weren’t invited included free marketers such as Rep. Paul Ryan, Rep. Tom Price, Sen. Richard Burr, Sen. Jim DeMint, and Obama’s personal friend, Sen. Tom Coburn.
By contrast, Sen. Bernard Sanders and Rep. John Conyers were on hand — both of them advocate a socialized, or single-payer, system.
The Obama administration’s unwillingness to consider free-market views wasn’t limited to the summit. TAS spoke to several professionals who took the Obama transition team up on its call to hold community meetings last December aimed at generating ideas on how to reform the health-care system. But those who came up with ideas focused on a consumer-based approach rather than a government-run one felt that their ideas were ignored.
“They called out for everyone to have all of these town meetings, but if your town meeting didn’t have a conclusion that agreed with theirs, they said ‘thank you very much’ and never came back to you,” said Dr. Marcy Zwelling-Aamot, who participated in a meeting in Long Beach, California, along with a coalition of local lawmakers, hospitals, providers, and concerned residents.
More here:http://spectator.org/archives/2009/03/11…

Diabetic Skin Care

Epidemiology

Diabetes mellitus is characterized by high blood glucose (hyperglycemia) which can be due to: a) decreased production of insulin (called Type I diabetes mellitus) due to destruction of the pancreas on an autoimmune basis or b) decreased peripheral sensitivity to insulin (called type II which also has some decreased production of insulin by the pancreas) associated with obesity and lack of physical activity. Only about 5-10% of the total have type I disease, the rest have type II.

The most recent statistics available (2005) reveal 20.8 million people (7% of the population) with diabetes of which 14.6 million were actually diagnosed leaving 6.2 million unaware of the presence of this serious disease. Moreover, its prevalence has increased 40% in the last decade and is expected to increase by 165% between 2000 and 2005 (figure 1). It has been estimated that fully 1/3 of the population born in 2000 will develop diabetes. In addition to patient suffering and disability, the economic impact in direct and indirect costs is enormous, amounting to $132 billion in 2002 representing 1/10th of all health care costs.

There were 224,092 deaths attributable to diabetes in the USA in 2002 (probably an underestimation). The risk for death in patients with diabetes is twice that for people of the same age without diabetes, and this decreased longevity is due to cardiovascular disease. Diabetes increases the risk of heart disease and stroke 2-4 fold over that for people without diabetes. Its microvascular complications of retinopathy, nephropathy, and neuropathy make diabetes mellitus the leading cause of blindness, end-stage renal disease, and non-traumatic lower extremity amputations in the U.S.A.2 The frequency of the last complication is increasing (figure 2).

Pathogenesis

The macrovascular and microvascular complications of diabetes are closely related to hyperglycemia and oxidative stress, which is when cells fail to detoxify the reactive oxygen species (ROS) produced during metabolism. Four hypotheses have been proposed to explain how hyperglycemia causes complications: 1) increased polyol pathway flux, 2) increased intracellular formation of advanced glycation end-products (AGE), 3) activation of protein kinase C (PKC) isoforms, and 4) increased flux through the hexosamine pathway.

A unifying concept is that hyperglycemia-induced mitochondrial superoxide overproduction activates these 4 pathways. Excess superoxide partially inhibits the glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH) thereby diverting upstream metabolites from glycolysis to pathways of glucose over-utilization. Superoxide anion achieves this by causing DNA strand breaks that result in activation of poly ADP ribose polymerase (PARP) which in turn ribosylates and deactivates GAPDH. By preventing their metabolism, this process increases energy substrates resulting in increased flux of dihydroxyacetone phosphate (DHAP) to diacylglycerol (DAG), an activator of PKC, and of triose phosphates to methylglyoxol, which is the main intracellular AGE precursor. Increased flux of fructose-6-phosphate to UDP-N-acetylglucosamine in the hexosamine pathway increases modification of proteins by O-linked N-acetylglucosamine and increased glucose flux through the polyol pathway consumes the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) and depletes GSH (reduced glutathione, a natural potent anti-oxidant).

Several mechanisms have been postulated to explain why increasing the polyol pathway flux is detrimental. These are sorbitol-induced osmotic stress, decreased (Na++K+) ATPase activity, increased cytosolic NADH/NAD+ and decreased cytosolic NADPH.

Activation of the hexosamine pathway results in intracellular glycosylation and donation of N-acetyl glucosamine to serine and threonine residues of transcription factors such as Sp1 resulting in increased production of factors such as plasminogen activator inhibitor-1 (PAI-1) and transforming growth factor beta 1 (TGF-beta 1).5

Production of intracellular AGEs damages target cells by three mechanisms. Intracellular proteins modified by AGEs have altered function (like neurotropism, axonal transport, and gene expression). Secondly, extra-cellular matrix components modified by AGE precursors interact abnormally with other matrix components and with the receptors for matrix proteins (integrins) on cells. Thirdly, plasma proteins modified by AGE precursors bind to AGE receptors (RAGE) on endothelial cells, mesangial cells, and macrophages inducing receptor-mediated production of ROS as a second messenger to activate the nuclear factor kappa B (NF-kappa B), a transcription factor causing pathological changes in gene expression.5

Hyperglycemia-induced activation of PKC has a number of pathogenic consequences by affecting expression of endothelial nitric oxide synthetase (eNOS), endothelin-1 (ET-1), vascular endothelial growth factor (VEGF), TGF-beta 1, and PAI-1, and by activating NF-kappa B and NAD(P)H oxidases. Increased eNOS and decreased ET-1 decrease blood flow causing hypoxia. Increased VEGF causes increased vascular permeability and angiogenesis. Increased TGF-beta leads to increased collagen, fibronectin, extra-cellular matrix, and basement membrane resulting in capillary occlusion. Increased PAI-1 decreases fibrinolysis leading to vascular occlusion. Increased NF-kappa B causes an increase in pro-inflammatory gene expression. Increased NAD(P)H oxidase causes increased ROS (resulting in DNA damage, oxidation of polydesaturated fatty acids in lipids, and oxidation of amino acids in proteins). These pathogenic mechanisms can all be characterized as a result of ROS effects on genes and proteins.5

Diabetic Skin

The skin of the diabetic is prematurely aged and is subjected to the problems of neuropathy, macrovascular disease, and microvascular disease. In addition, diabetes is associated with poor wound healing, susceptibility to infection, and decreased cell-mediated immunity. This battle may go on unrecognized to the naked eye and dictates a keen vigilance by both doctor and patient to prevent the dreaded complications of this disease. The struggle is against oxidative stress and inflammation, ischemia and necrosis.

Clinical manifestations

1. Diabetic dermopathy is the most common dermatological manifestation of diabetes and is due to microvascular changes. Because it is associated with but not specific for diabetes mellitus, it serves as a marker for the disease. This dermopathy is most often seen in diabetic men over the age of 50 but may also be seen in euglycemic diabetics and healthy individuals. The lesion is so named because of typical changes in the microvasculature. Irregularly shaped patches of skin with a depressed surface are found primarily over the anterior aspect of the lower legs but may occur on the upper arms and thighs and over bony prominences. The lesions are light brown in color due to extravasated red blood cells and deposition of hemosiderin in histiocytes. They appear in crops and resolve over 12-18 months. Since the lesions are asymptomatic, no specific treatment is required except to protect the area from trauma and secondary infection.

2. The skin of the diabetic foot is usually dry due to decreased sweating as a result of the autonomic neuropathy of diabetes. Sweating normally helps hydrate the stratum corneum, and dry skin is prone to callus formation with cracking and fissuring.

3. The “diabetic foot” is due to neurovascular and ischemic changes. It is a very serious complication of this disease. Loss of sensation means that the diabetic patient is no longer able to sense and avoid injuring agents in the environment. Thermal trauma can have horrific results. Even minor mechanical trauma to the skin of the diabetic foot can result in blisters, sores, and ulcers. This is compounded by motor loss to the intrinsic muscles of the foot leading to deformities including a high plantar arch and “hammer toes.” Bony prominences are created at the heel, toes, and metatarsal heads that become pressure points over which the skin can break down. This can lead to ulceration; infection of skin, soft tissues, and bone (osteomyelitis); gangrene (which can be either “wet” due to necrosis with infection or “dry” due to necrosis without infection); and ultimately amputation. The skin over pressure points can become thickened as a callus or corn or develop blisters that can get infected. The skin between the toes can become macerated which fosters secondary infection by bacteria and fungi. The bones of the feet can degenerate producing fractures (Charcot foot). One dreaded complication from this is a “rocker-bottom foot” that often results in skin breakdown and infection. A “diabetic foot” is usually asymptomatic until late in the game. Special attention is required: the patient should inspect his or her feet daily to avoid the complication, and a physician with expertise in this field is required for optimal results.

Treatment:

Control of hyperglycemia: The first step in controlling hyperglycemia in type II diabetics is diet and exercise. Then oral hypoglycemic agents are added of which there are many. Ultimately, insulin may be required by injection. Insulin is the first therapeutic step in type I diabetics. Unfortunately, control of blood glucose is difficult particularly in type II patients probably related to poor compliance. It is at this level that the patient can be most helpful. Make sure the patient takes control of their blood glucose, exercises, has proper diet, attends to their skin, and uses appropriate medications. Patients should check their blood sugar often and their feet daily. The best results come from treatment based on pathogenesis, and prevention is the name of the game.

Pharmacology

Corneotherapy is made possible by what is known as the 500 Dalton Rule. The 500 Dalton Rule is used in the development of topical drugs and trans-dermal delivery systems. The skin’s barrier is effective in blocking molecules with an atomic weight more than 500 Daltons, but molecules of less weight pass through the skin’s barrier. Topical drugs like cyclosporine, tacrolimus, and ascomycins can be effectively delivered through the skin because the molecules of these drugs are all smaller than 500 Daltons.

While the stratum corneum’s physicochemical barrier resists the penetrations of large molecules, smaller molecules with a molecular weight of less than 500 Daltons pass transcutaneously. Molecular size is an important factor governing passage of substances through the skin, giving substances with higher molecular weights self-limiting properties. Passive delivery of substances, due to their low molecular weight, provides novel delivery opportunities. Included in these low molecular weight substances are vitamins, amino acids, ?-3 and ?-6 essential fatty acids, and antioxidants like hydroxytyrosol.

Instructions for Patients to Prevent Diabetic Foot Problems

You should start taking good care of your feet. Set a time every day to check them. Now is the time for you to play an active role in your health care with these 10 steps:

1.Test your blood glucose often. Work with your health care team to keep your blood glucose in your target range with proper diet and exercise.

2.Avoid foot problems by early detection of changes before they get worse. Look at your bare feet daily for red spots, cuts, swellings, and blisters. If you cannot see the bottoms of your feet, use a mirror or ask someone for help.

3.Get active. Plan your physical activity program with your health care team.

4.Get informed. Ask your doctor about Medicare coverage for special shoes (orthotics).

5.Wash (not soak) your feet every day in lukewarm water and dry them carefully, especially between the toes.

6.Keep your skin soft and smooth. Rub a thin coat of skin cream over the tops and bottoms of your feet, but not between your toes.

7.If you can see and reach your toenails, trim them when needed. Trim your toenails straight across and file the edges with an emery board or nail file.

8.Wear shoes and socks at all times. Never go barefoot. Wear comfortable shoes that fit well and protect your feet. Check inside your shoes before wearing them. Make sure the lining is smooth and there are no objects inside.

9.Protect your feet from hot and cold. Wear shoes at the beach or on hot pavement. Don’t put your feet into hot water. Test water before putting your feet in it just as you would before bathing a baby. Never use hot water bottles, heating pads, or electric blankets. You can burn your feet seriously without realizing it.

10.Keep the blood flowing to your feet. Put your feet up when sitting. Wiggle your toes and move your ankles up and down for 5 minutes, two (2) or three (3) times a day. Don’t cross your legs for long periods of time. Don’t smoke!

Remedy® Description:

Clinical Pharmacology: The active ingredient in these preparations is dimethicone 1.5% that protects the skin. Olivamine® is a patent pending blend of antioxidants and anti-inflammatory agents that helps repair cell membranes and restore cells to a healthy state. Olivamine® contains the following:

Hydroxytyrosol

3,4-dihdroxyphenylethanol (hydroxytyrosol: DOPET) is the major component in the phenolic fraction of olive oil. It is a hydro-soluble and lipid soluble molecule that is an efficient scavenger of peroxyl radicals. Experiments demonstrate that DOPET effectively counteracts the cytotoxic effects of reactive oxygen species (ROS) in various human cellular systems. In studies using DOPET pre-incubated cells, it was found that damage due to oxidative stress, such as lipid peroxidation and alterations of cell permeability, could be prevented and that DOPET exerted a protective effect against H2O2 induced oxidative hemolysis.

Glycine

Altering cellular osmolality to a hyperosmotic state results in a decrease in adenosine triphosphate (ATP) allied with necrosis and resultant necrosis. Glycine is a cytoprotectant against injury by ATP-depletion. Glycine protects ATP-depleted cells by low affinity interactions with multimeric channel protein, stabilization of which may other wise lead to formation of pathological pores. Such porous defects in membranes of ATP-depleted cells have been characterized recently, showing definable exclusion limits for molecules of increasing sizes. Glycine provided during ATP-depletion blocked the development of membranous pores completely. The relationship between necrosis and an extracellular depletion of ATP makes its protection and restoration imperative during the prelethal stages of necrosis or early necrosis.

L-Taurine

L-Taurine can act as a direct antioxidant that scavenges or quenches oxygen free radicals intracellularly to block ROS mediated cell death. The beneficial effects of the ROS-scavenging capacity of L-taurine include attenuation of lipid peroxidation, reduction of membrane permeability, and inhibition of intracellular oxidation in different cells. Taurine prevents high glucose induced apoptosis in endothelial cells thru ROS inhibition and stabilization of intracellular calcium. Apart from its effect on antioxidant defense, L-taurine also functions as a principle modulator of intracellular Ca2+ homeostasis.

N-Acetyl-L-Cysteine

In research conducted by the Department of Microbiology and Immunology, SUNY Buffalo School of Medicine, Buffalo, NY, and the Free Radical & Radiation Biology Program, Department of Radiation Oncology, the University of Iowa, Iowa City, Iowa, we investigated the hypothesis that NAC-induced free radical-signaling delays G0/G1 cells progression to S phase by regulating the cell cycle regulatory protein cyclin D1 and the free radical-scavenging enzyme manganese superoxide dismutase (MnSOD). Treatment with NAC resulted in increased cellular glutathione levels indicating a shift to a more reducing environment. This shift in cellular redox environment was associated with delayed progression from G0/G1 to S. NAC treatment resulted in a decrease in cyclin D1 and an increase in MnSOD protein levels. The absence of NAC-induced G1 arrest in fibroblasts over-expressing cyclin D1 (or a non-degradable mutant of cyclin D1-T286A) indicates cyclin D1 regulates this delay in G0/G1 to S progression. These results support the hypothesis that cellular redox environment regulates cellular proliferation via regulating cell cycle regulatory protein levels. Furthermore, our results also suggest that inclusion of NAC in skin care formulations might help in appropriate wound healing by controlling proliferation and preventing scarring.

L-Proline

DNA synthesis is a vital part of cell life. In studies done in vivo and in vitro, L-proline was found to be the only amino acid that was involved in the stimulation of DNA synthesis. Further, epidermal growth factor (EGF) elicited no response without the addition of L-proline. Proline-deficient media such as Leibovitz’s L-15, Eagle’s minimal essential, and Dulebecco’s modified minimal essential did not induce DNA synthesis. However, using media such as Williams E, McCoy’s 5A and Ham’s F-12, which are rich in L-proline, there was DNA synthesis and marked proliferation. L-Proline is essential for the induction of cellular proliferation in vivo and in vitro through its effect on synthesis of intracellular collagen.

Vitamin B6 (Pyridoxine)

The term vitamin B6 is used to describe all biologically inter-convertible forms of pyridoxine including pridoxine, pyridoxal, pyridoxal 5-phosphate, and pyridoxamine. Vitamin B6 is an essential co-factor in numerous enzymatic reactions involved primarily in amino acid metabolism. In addition, vitamin B6 functions as an antioxidant by interacting with singlet molecular oxygen during oxidative stress.

Vitamin B3 (Niacinamide)

Niacinamide is a precursor of the coenzyme nicotinamide adenine dinucleotide (NAD+) used to generate ATP in the mitochondrial electron-transport chain. Niacinamide is involved in DNA integrity and maintains phosphatidylserine membrane asymmetry to prevent cellular inflammation and phagocytosis. Current research demonstrates that niacinamide prevents the induction of caspase-8, caspase-1, and caspase-2 activities during cellular injury. The cytoprotectant effects of niacinamide are involved in the maintenance and preservation of cellular membranes.

Methylsulfonylmethane (MSM)

Methylsulfonylmethane (MSM) is a naturally occurring organic compound containing 34% elemental sulfur. Sulfur is critical in the formation of collagen. The flexibility of bonds between cells, including skin, is dependent upon sulfur. MSM provides a bioavailable from of sulfur and supports the body’s ability to produce N-acetyl-L-cysteine and L-taurine that are sulfur-containing amino acids. MSM is an important volatile component in the sulfur cycle. Topically applied MSM is keratolytic through the formation of hydrogen sulfide. MSM aids in wound healing via keratin. Compounds containing sulfur are found in all body cells and are indispensable for life. Low levels of MSM are implicated in slow wound healing.

Indications and Usage

Remedy® with Olivamine® temporarily protects and helps relieve chapped or cracked skin in patients with dry skin or diabetes mellitus. It is useful in prevention of skin complications from diabetes.

Contraindications

Do not use products on deep or puncture wounds, animal bites, or serious burns.

Warnings

These products are recommended for external use only.

Precautions

When using this product do not get into eyes. Stop use and ask a physician if the condition worsens, symptoms last longer than 7 days, or symptoms clear up and then return within a few days. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. Protect the products from freezing and excessive heat.

Adverse Reactions

An allergic skin rash is possible with any of the components. If redness, itching, or hives occur, stop the product and seek medical care.

Dosage and Administration

Apply cleansing lotion to wet or dry skin and rub gently. Rinse or wipe with a moistened cloth. The cleanser acts without lathering. Apply the cream liberally until the entire area is covered. Both the cleansing lotion and the repair cream can be used as needed.

Dr. Darlene McCord is one of the two founders of McCord Research. As senior researcher, she brings a unique blend of scientific credentials to the position. Through her leadership, the company has achieved worldwide recognition in the OTC Drug and Medical Device categories. Her field of specialty is corneotherapy, focusing on the transport of small molecules across the stratum corneum for treatment of skin disorders associated with distressed and wounded skin. Dr. Darlene E McCord is widely published on subjects related to immunodermatology and corneotherapy.

Is This True Or False?? I Dnt Care How Long This Is!!?

Why don’t the hairs on your arms get split ends?
Can you get cornered in a round room?
Do illiterate people get the full effect of Alphabet soup?
If electricity comes from electrons, does morality come from morons?
Isn’t Disney World just a people trap operated by a mouse?
Who was the first person to say, “See that chicken over there … I’m gonna eat the first thing that comes out if its butt”?
Who was the first person to look at a cow and say, “I think I’ll squeeze these dangly things here and drink what comes out”?
Why did Yankee Doodle name the feather in his hat Macaroni?
If you pay for a vacation and your plane crashes on the way there, do you get you money back? (Granted you lived)
Why does the last piece of ice always stick to the bottom of the cup?
Are marbles made of marble?
Can you breathe out of your nose and mouth at the same time?
“Cute as a button” Is that supposed to be a compliment? Since when are buttons cute?
Can it be cloudy and foggy at the same time?
Can a fire truck park in the fire lane?
If the swat team breaks down your door do they have to replace it later?
Aren’t the ‘good things that come to those who wait’ just the leftovers from the people that got there first?
When French people swear do they say pardon my English?
Can you make a candle out of your earwax?
Are children who act in rated ‘R’ movies allowed to see them?
If the sky is the limit, then what is space, over the limit?
If Hooters were to become a door-to-door service would they have to change their name to Knockers?
Why do the numbers on phones go down while the numbers on calculators go up?
Do coffins have lifetime guarantees?
Why is there a top line on lined paper if we never use it?
When people say, “I’m so tired it’s not even funny” or “my head hurts so much it’s not even funny”, why would it even be funny in the first place?
Do stairs go up or down?
Why do bullies always ask “what’s your problem” when they’re obviously not going to solve it?
Do they have burglar alarms at Christian bookstores?
Can you put a gay man in a straight jacket?
If you swallow a burp does it turn into a fart?
Why is it that when adults have multiple personalities they are put in an mental hospital, but when a child has imaginary friends it’s cute?
Do Jewish vampires avoid crosses or Stars of David?
Can you still say “Put it where the sun don’t shine ” on a nude beach?
How come French fries are not considered vegetables, since they are just deep fried potatoes?
If someone’s peeing and halfway through they die, would they keep pissing or stop?
Are people who are allergic to nuts allergic to coconuts too?
Do the actors in the re-enactments on Americas most wanted, ever get arrested (because they were seen on TV portraying the criminal)?
Can a person with no ears wear glasses?
If you rented a movie and were late returning it and then you died would someone you knew or a family member have to pay the late fee?
If you made biscuits with chocolate milk instead of regular milk, would they taste chocolaty?
What if you were to ask a genie to grant you more than three wishes for one of you wishes?
Why doesn’t baking soda freeze?
Do bald people get dandruff?
Do the actors on Unsolved Mysteries ever get arrested because they look just like the criminal they are playing?
“What was Captian Hook’s name before he had a hook for a hand?”
If there was a crumb on the table and you cut it in half, would you have two crumbs or two halves of a crumb?
When a store has double doors why do they only let you use one of them?
How do “do not walk on grass” signs get there?
Whats a question with no answer called?
Why do we say “heads up” when we actually duck?
Are there pink lemons that make pink lemonade?
Doesn’t a lightning rod on top of church show a lack of faith?
How come lotion is colored, but when you put it on, it doesn’t turn your skin that color?
Are tomatoes fruits or vegetables?
Isn’t it weird that all year round your parents tell you not to play with fire, but on Independence Day they hand you a package of explosives, a lighter, and say have fun?
How come only your fingers and toes get wrinkly in the shower and nothing else does?
Why does the Easter bunny carry eggs? Rabbits don’t lay eggs.
Why is there a little countdown (like 8, 7, 6, 5, 4) near the bottom of the copyright info page in the beginning of many books?
If a pack of gum says that each piece is 10 calories, is that amount just chewing the gum, or also for swallowing it?
Why do cats like to dig their paws into something before they lay down on it?
When an atheist swears on a Bible before they testify in court do they have to tell the whole truth and nothing but the truth since they don’t believe in God?
Is it possible to be allergic to water?
What is the point in saying “may I ask” and then follow it up with a question?
Why is there never a full English dinner or tea but there is always a full English breakfast?
Why don’t they make Root Beer flavored ice cream? Wouldn’t it be better than root beer floats?
If a General is a higher ranking officer than a Major, then why is a major illness worse than a general illness?
If a baseball player hits a home run over the fence, but then dies before he can run around the bases, does the home run count?
Can a unborn baby fart or burp?
Why does jello have a smell when you add the powder in the water, but when it “gels” the scent virtually disappears?
Why is it called a soap opera when nobody sings?
If French kissing is a big thing in America, how do French people react to normal American kissing?
Can you “zone out” and be “in the zone” at the same time?
Do you wake up or open your eyes first?
Is the vice president’s wife called the second lady?
If a stripper gets breast implants can she write it off on her taxes as a business expense?
If your eyes are crossed, do your tears fall straight?
Why do child labor laws not prohibit children from acting in movies?
If a vampire were Jewish would his Sabbath start at sunrise?
Why do people say “The alarm just went off” when really it just came on?
Do they put underwear on corpses?
Do bubbles freeze in winter?
What sound does a bunny make?
If you had only one hand, would second hand smoking effect you?
Do suicide hotlines have hold?
Have you ever wondered why in the 1500′s nude photos/painting were art, while today it’s pornography?
If you are old and are in a bathtub how would you know if you have been in there too long?
If you can see your breath outide on a cold day, could you see your fart?
If you wear contact lens and you died with them in your eyes, do they take them out?
Why do people call it an ATM machine, but they know it’s really saying Automated Teller Machine Machine?
Why do you have to “put your two cents in” but it’s only a “penny for your thoughts”? Where’s that extra penny going too ?
Why is it when we laugh in school the teachers say do you find something funny? When obviously we do?
strangers, yet on Halloween, its encouraged! Why is that ?
364 days of the year, parents tell their kids not to take candy from
If all of the Acme stuff doesn’t work, why does Wile Coyote keep buying their products?
If your name is Mr. Crunch, and you joined the Navy, would you eventually be Captain Crunch? Can you cry under water?
Does Hawaiian Punch come from Hawaii?
Just what was the “Baby On Board” sign for? Did it help us decide which car not to hit in case of an accident?
When a boy is named after his dad, he is called ‘Junior,’ but what do you call a girl that is named after her mother?
Do the air bubbles that are created when you fart in water, smell when they pop?
How important does a person have to be before they are considered assassinated instead of just murdered?
If a bunch of cats jump on top of each other, is it still called a dog pile?
Why is Donkey Kong called “DONKEY” Kong if he’s a monkey?
If money doesn’t grow on trees then why do banks have branches?
If you went back in time and killed your mother would you disappear the moment you killed her?
Who gets to keep the pennies in a wishing well?
Why do we teach kids that violence is not the answer and then have them read about wars in school that solved America’s problems?
Do the security guards at airports have to go through airport security when they get to work?
Why do they call the small candy bars the “fun sizes”? Wouldn’t be more fun to eat a big one?
Why is “number” abbreviated as “no”? When there is no “o” in number?
Is sign language the same in languages other than English?
If you die and you have a broken leg do they take the cast off?
Since a running back runs forward, why is he called a running back?
Why is it that when babies are born they only weigh like 7 lbs yet the mom weighs 30 lbs more?
When something’s funny why is it called a “knee-slapper” when you actually slap your thigh?
Why is it the TWELVE days of Christmas when there is only one day of Christmas?
Since bread is square, then why is sandwich meat round?
How come only car keys are the only keys with teeth on both sides?
Why do we wash behind our ears? Who really looks there?
How come you pay an extra 25 cents to get something put on your hamburger but they don’t take off the price if you get something taken off?
If I had my legs amputated, would I have to change my height and weight on my driver’s license?
Why do they put the names of football teams on baseball caps?
Why is snow white and ice clear? Aren’t they just different forms of water?
Why is Charlie short for Charles if they are both the same number of letters?
Did Noah have woodpeckers on the ark? If he did, where did he keep them?
Do movie producers still say lights, camera, and action when it is a dark scene?
How come popcorn isn’t a vegetable?
Can bald men get lice??
Why do people say, “You can’t have your cake and eat it too”? Why would someone get cake if they can’t eat it?
Is Jerry Garcia grateful to be dead?
Why is it that its good to score under par in golf but its bad to be “under par” in any thing else?
If overalls are held up by the snaps at the top, then why do they have belt loops?
Why aren’t safety pins as safe as they say they are?
What happens if your snot freezes in your nose?
Why are Pringles curved?
If you were a genie and a person asked you this wish, “I wish you would not grant me this wish” what would you do?
If the president were gay, would his husband be the first man?
Why can’t a baby cry while it’s inside its mother?
If a missing person sees their picture on a milk carton that offers a reward, would they get the money?
Why did Mary own a little lamb?
If mars had earthquakes would they be called marsquakes?
Why do all superheroes wear spandex?
Why are people allowed to put naked statues outside but why can’t we run outside naked?
Which way does a compass point in space?
Why is the 0 on a phone after 1 and not before 1?
Why is a square meal served on round plates?
Why is it when some products you have to turn it upside down to read the directions, and the directions say do not turn upside down?
Why do you get in trouble for blocking an exit when you’re standing in the doorway? In case of an emergency, wouldn’t you run out, too, therefore NOT blocking the exit?
You know the expression, “Don’t quit your day job?” Well what do you say to people that work nights?
If something “goes without saying,” why do people still say it?
Why do companies offer you “free gifts?” Since when has a gift NOT been free?
Why do dogs sniff other dog’s bottoms to say hello, why don’t they just bark in their face or something?
If your sick for one week and on one of those days they had to cancel school because of snow, do you have to make up that day in June?
Why can’t you get a tan on your palms?
Why is vanilla ice cream white when vanilla extract is brown?
Why doos shaped macaroni taste better than the normal kind?
Why do you go “back and forth” to town if you really must go forth before you go back?
Why is it when we talk to God we are praying, but when God talks to us we are put into the loony bin?
Why is toilet bowl cleaning liquid only blue?
Do they have girl’s bathrooms in gay bars?
Why isn’t chocolate considered a vegetable, if chocolate comes from cocoa beans, and all beans are a vegetable?
Why is there that little space inside strawberries, as if it was meant for a pit, and then the seeds are on the outside?
If heat rises, then shouldn’t hell be cold?
If a fork were made of gold would it still be considered silverware?
How come you play at a recital, but recite at a play?
Why is chopsticks one of the easiest songs to play on the piano, but the hardest thing to eat with?
What happens if you put this side up face down while popping microwave popcorn?
Can mute people burp?
Why is it that when you get out of a swimming pool, your urine is hotter when you use the restroom?
Why is it that when things get wet they get darker, even though water is clear??
Isn’t it funny how the word ‘politics’ is made up of the words ‘poli’ meaning ‘many’ in Latin, and ‘tics’ as in ‘bloodsucking creatures’?
Have you ever noticed that if you rearranged the letters in mother in law, they come out to Woman Hitler?
Why are the commercials for cable companies on cable but not on regular television? Don’t they want the people without cable to buy the cable?
Wouldn’t it be smart to make the sticky stuff on envelopes taste like chocolate?
Why are people so scared of mice, yet we all love Mickey Mouse?
Why is it that if something says, “do not eat” on the packaging it becomes extra tempting to eat?
How come we say ‘It’s colder than hell outside’ when isn’t it realistically always colder than hell since hell is supposed to be fire and brimstone?
In that song, she’ll be coming around the mountain, who is she?
Why is it illegal to park in a handicapped parking space but its ok to use a handicapped toilet?
If Dracula has no reflection, how comes he always had such a straight parting in his hair?
Why do they put “for indoor or outdoor use only” on Christmas lights?
Does the President have to pay taxes?
Why are they called stairs inside but steps outside?
If you mated a bull dog and a shitsu, would it be called a bullshit?
How fast do hotcakes sell?
If you wore a teflon suit, could you ever end up in a sticky situation?
Why is an alarm clock going “off” when it actually turns on?
Why are semi-trucks bigger than regular trucks?
What is a male ladybug called?
Since we see little birdies when we just get knocked out, what do little birdies see when they just get knocked out??
If a person owns a piece of land do they own it all the way down to the core of the earth?
Can a guy named Nick have a ‘nick’name?
Do cows drink milk?
How come some Little Debbie snack cakes come in a twin pack and others are wrapped individually?
Why is it called football when you hardly use your feet?
Why do they call it an escalator if it takes you down?
How did the headless horseman know where he was going?
If it’s zero degrees outside today and it’s supposed to be twice as cold tomorrow, how cold is it going to be?
Why is it called a TV set when there is only one?
Why would superman want to leap over the tallest building in a single bound if he can fly?
How do they get those boats in those glass bottles?
If someone can’t see, they’re blind and if someone cant hear, they’re deaf, so what do you call people who can’t smell?
Why is the name of the phobia for the fear of long words Hippopotomonstrosesquippedaliophobia?
Can a hearse driver drive a corpse in the Car Pool lane?
Why do they call it “head over heels in love” If our head is always over our heels?
Why do they call them guidance counselors when all counselors do is offer guidance?
Why do British people never sound British when they sing?
How come no matter what color the liquid is the froth is always white?
Why do they call it your “bottom”, when it’s really in the middle of your body?
If you tell someone they are being judgmental aren’t you being judgmental yourself?
Why do they call it a RUNNING BACK when he is running forward?
Why does everyone speak different languages and have different accents if we all originally came from the same place?
Why is it we have the weight of the world on our shoulders but have to get it off our chests?
If you decide that you’re indecisive, which one are you?
If an anarchist group attained political power, would they by principle have to dissolve their own government?
If Luke took a bath, would the water be lukewarm?
Why doesn’t the glue in the bottle dry up?
Why do the call the angel of death an angel if all it does is bring pain and suffering?
How do you handcuff a one-armed man?
Can blind people be dyslexic when they read Braille?
Why do we say “bye bye” but not “hi hi”?
Why is it you can walk down a road, even if it goes uphill?
If one man says, “it was an uphill battle,” and another says, “it went downhill from there,” how could they both be having troubles?
If you’re caught “between a rock and a hard place”, is the rock not hard?
If your born at exactly midnight is your birthday on both those days?
Do the different “M&M’s”® colors taste different?
Why don’t you hear thunder with heat lightning?
Why do donuts have holes?
Why can’t you eat pancakes for dinner?
Why do we feel blue? and what color does a smurf feel when they are down?
what does the K in K-mart actually stand for?
What does OK actually mean?
If the universe is expanding, what is it expanding into?
If you were on a plane going the speed of sound and walked from the back of the plane to the front, would you be walking faster than the speed of sound?
In some books, why do they have blank pages at the very end?
Why does caregiver and caretaker mean the same thing?
Why are things typed up but written down?
Why do old men have hair in their ears?
Why in baseball is it called the World Series if it is only played in the U.S.A & Canada?
How do you throw away a garbage can?
How many licks does it take to get to the center of a tootsie pop?
Why do they call them “Animal Crackers” when there not even crackers…they’re cookies?
Why does “closing up” a shop and “closing down” a shop mean the same thing?
If it is a 50 mph per hour wind and you drive your car at 50mph downwind, if you stick your head outside would you feel the wind?
If you have x-ray vision, and you can see through anything, wouldn’t you see through everything and actually see nothing?
nearby town, do you have to pay for the property damage?
If you own a piece of land and there is an volcano on it and it ruins a
If a water spins clockwise when it drains in the northern hemisphere, and water spins counterclockwise when it drains in the southern hemisphere…which way does it spin at the equator?
Have you ever thought what life would be like if your name was Anonymous? You’d get credit for everything nobody wanted credit for?
If you had x-ray vision, but closed your eyes, could you still see?
What do you say when someone says you’re in denial, but you’re not?
Why do they call it 2% milk, if its 2% fat, not milk?
Do siamese twins pay for one ticket or two tickets when they go to movies and concerts?
Do birds pee?
If you are born on February 29 of a leap year, when is your birthday?
When a male is elected president and his wife is called the First Lady. What would a lady’s husband be called if she were elected president?
Can dogs have dog days?
Why does blow and suck mean the same thing when we describe something being crap?
Why do they call the clock where you punch your time card called a “time” clock? Aren’t all clocks “time” clocks?
Does anyone actually kill two birds with one stone?
Why did Superman wear his briefs on the outside of his tights?
Why do people say heads up when you should duck?
Why do radio operators say “niner” instead of just “nine”?
Do dumped farmers get John Deere letters?
Do pigs pull ham strings?
On a telephone, why does ABC start on the number 2 and not 1?
Do sheep get static cling when they rub against one another?
Isn’t it scary that the word “therapist” is the same as the words “the” and “rapist” put together?
Why do people, such as S.W.A.T or Seals wear the bulletproof vests where you can see them? Wouldn’t people aim for their head or crotch?
11 months ago
Additional Details
11 months ago
If Dracula has no reflection, how comes he always had such a straight parting in his hair?
Why do they put “for indoor or outdoor use only” on Christmas lights?
Does the President have to pay taxes?
Why are they called stairs inside but steps outside?
If you mated a bull dog and a shitsu, would it be called a bullshit?
How fast do hotcakes sell?
If you wore a teflon suit, could you ever end up in a sticky situation?
Why is an alarm clock going “off” when it actually turns on?
Why are semi-trucks bigger than regular trucks?
What is a male ladybug called?
Since we see little birdies when we just get knocked out, what do little birdies see when they just get knocked out??
If a person owns a piece of land do they own it all the way down to the core of the earth?
Can a guy named Nick have a ‘nick’name?
Do cows drink milk?
How come some Little Debbie snack cakes come in a twin pack and others are wrapped individually?
11 months ago
Why do people call it an ATM machine, but they know it’s really saying Automated Teller Machine Machine?
Why do you have to “put your two cents in” but it’s only a “penny for your thoughts”? Where’s that extra penny going too ?
Why is it when we laugh in school the teachers say do you find something funny? When obviously we do?
strangers, yet on Halloween, its encouraged! Why is that ?
364 days of the year, parents tell their kids not to take candy from
If all of the Acme stuff doesn’t work, why does Wile Coyote keep buying their products?
If your name is Mr. Crunch, and you joined the Navy, would you eventually be Captain Crunch? Can you cry under water?
Does Hawaiian Punch come from Hawaii?
Just what was the “Baby On Board” sign for? Did it help us decide which car not to hit in case of an accident?
When a boy is named after his dad, he is called ‘Junior,’ but what do you call a girl that is named after her mother?
11 months ago
I didnt wonder all these. I found them at bored.com. Theres thousands of them.
11 months ago
Why are dandelions considered weeds when daisies are considered flowers?
Why does Sea World have a seafood restaurant?
Whenever an adult is kidnapped why isn’t it called adultnapped??
Why do blacklights look purple?
Did Yankee Doodle name the feather, hat, town, or his pony Macaroni?
Why is it that people duck in the rain, do they really think the rain won’t hit them?
How come the Bible is the most stolen book, and one of the ten comandments is “thou shall not steal”?
Why isn’t the caps lock capitalized?
If there’s a hole straight through the earth, from the south pole to the north pole, and you jump through it what would happen? would you keep falling forever, or fall back down when you get to the middle, or is it physically impossible?
If someone with a nostril ring takes it out, then blows their nose, do they have to cover that hole as well as their nostril holes so that snot does’nt blow out everywere
Isn’t it weird that if you rearange the word “teacher” you get cheater

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